Theformulation of a potential delivery system based on liposomes (Lips) formulated fromsoy lecithin (SL) for paclitaxel (PTX) was\nachieved (PTX-Lips). At first, PTX-Lips were prepared by thin film method using SL and cholesterol and then were characterized\nfor their physiochemical properties (particle size, polydispersity index, zeta potential, and morphology). The results indicated\nthat PTX-Lips were spherical in shape with a dynamic light scattering (DLS) particle size of 131 �± 30.5 nm. Besides, PTX was\nefficiently encapsulated in Lips, 94.5 �± 3.2% for drug loading efficiency, and slowly released up to 96 h, compared with free PTX.\nMore importantly, cell proliferation kit I (MTT) assay data showed that Lips were biocompatible nanocarriers, and in addition the\nincorporation of PTX into Lips has been proven successful in reducing the toxicity of PTX. As a result, development of Lips using\nSL may offer a stable delivery system and promising properties for loading and sustained release of PTX in cancer therapy.
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